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Men now have another good reason to consider taking finasteride, a well-known generic drug that shrinks an enlarged prostate and reduces the risk of getting prostate cancer by 25 percent.

A new study from the Southwest Oncology Group strongly suggests that for men at risk of the disease - which strikes one in six men - finasteride also raises the odds that physicians will find fast-growing prostate cancers early, when they are most easily treatable.

It appears that a man concerned about prostate-cancer risk, who is having a PSA test on a regular basis, will not only reduce his risk of prostate cancer if he takes finasteride, but will help find the cancers that pose the highest risk, says Ian M. Thompson, M.D., the study’s senior author and a urologist at the University of Texas Health Science Center in San Antonio.

The new results, embargoed until 4 p.m. Sept. 11, appear online ahead of print publication Sept. 18 in the Journal of the National Cancer Institute.

“This report provides an important interpretation of results that confounded an overall favorable interpretation of the Prostate Cancer Prevention Trial initially, and should help lessen fears that finasteride somehow causes more aggressive prostate cancer,” says Frank L. Meyskens, Jr., M.D., Southwest Oncology Group associate chair for cancer control and prevention.

The Southwest Oncology Group (SWOG), headquartered at the University of Michigan and one of the nation’s largest National Cancer Institute-sponsored clinical trial networks, conducted the study to further analyze data from its National Cancer Institute-sponsored 18,882-man seven-year Prostate Cancer Prevention Trial, which in 2003 found that finasteride was an effective prevention agent. The Food and Drug Administration has not approved finasteride for use in cancer prevention; the drug is approved for treating enlarged prostate.

Four years ago, Southwest Oncology Group researchers closed the Prostate Cancer Prevention Trial (PCPT) early to report very good news. Study results showed that finasteride, commonly used to treat enlarged prostate, could also make a man one-fourth less likely to get prostate cancer.

But that positive overall result - which potentially could keep around 50,000 men from developing prostate cancer each year - was clouded by a troubling finding: Men who took the drug but still developed prostate cancer by the end of the study had higher rates of detected high-grade tumors, an aggressive form of the disease, than did men in the placebo group.

The follow-up study, along with two others published recently, strongly suggests that finasteride makes it easier for physicians to detect high-grade cancers early by improving screening tests and prostate biopsy itself. The two previous studies show that finasteride improves the effectiveness of the two main measures of possible problems: digital rectal examination and the PSA (prostate specific antigen) blood test, which measures hormone changes associated with the disease. In some men who have low PSA test results, cancer is present but not found in time.

“Generic Finasteride makes the PSA test perform better, so we can find the cancer earlier,” Thompson says. “Our current study also shows that by shrinking the prostate gland, finasteride makes a biopsy more sensitive for any cancers that are present.” That increased accuracy is very important, he adds, because if a biopsy reveals a slow-growing cancer but fails to spot a fast-growing one, a doctor and patient may take a “wait and see” approach when prompt treatment is actually needed.

In part because of concerns about possible drawbacks, most urologists, when asked about finasteride, say they seldom prescribe it as a prevention drug, despite the positive 2003 PCPT findings, Thompson says. Now, with several studies allaying concerns about the drug’s possible drawbacks, including concerns about sexual dysfunction, Thompson believes men should be told routinely about the potential benefits of finasteride when they come to the doctor’s office for a PSA test, in much the same way patients at risk of heart disease are told about the benefits of statin drugs.

When the PCPT trial results were announced in 2003, it was unclear whether finasteride produced biological changes that could lead to more high-grade cancers. Researchers in the follow-up study analyzed tissue from biopsies and in men in the finasteride and placebo groups to compare hormonal levels and disease extent. They compared prostate size at the time of biopsy in the two groups. They also examined tumor grade and extent in men in the study who went on to have their prostates removed.

They found no significant differences in degenerative hormone changes when they examined high-grade tumor biopsies in men in both groups. However, the men taking finasteride had smaller prostates. Their biopsies correctly identified a higher proportion of high-grade tumors found later when their prostates were removed, compared to men in the placebo group.

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Alli (orlistat) Weight Loss Drug Available OTC

The U.S. Food and Drug Administration approved orlistat capsules, branded as alli, as an over-the-counter (OTC) treatment for overweight adults in February, 2007. The drug had previously been approved in 1999 as a prescription weight loss aid, whose brand name is Xenical). The OTC preparation will have a lower dosage than prescription Xenical and is produced and sold by GlaxoSmithKline under the name of Alli.

Unlike appetite suppressants, orlistat (Xenical) works as a weight loss aid by acting upon the function of the gastrointestinal tract. The drug binds to an enzyme known as gastrointestinal lipase and inhibits the action of this enzyme, which plays a role in breaking down fats for absorption in the GI tract. As a result, up to 30% of ingested fat is not absorbed by the body.

Orlistat alli is recommended only for people 18 years of age and over in combination with a diet and exercise regimen. People who have difficulties with the absorption of food or who are not overweight should not take orlistat. Overweight is defined by the U.S. National Institutes of Health as having a body mass index (BMI) of 27 or greater.

Orlistat alli can be taken up to three times a day, with each fat-containing meal. The drug may be taken during the meal or up to one hour after the meal. If the meal is missed or is very low in fat content, the medications should not be taken. Because of its interference with absorption of fat from the GI tract, the absorption of the fat-soluble vitamins (A, D, E, and K) may also be affected in people taking orlistat. It is recommended that those taking orlistat also take a daily multivitamin supplement containing these vitamins

What is Alli?

Alli (pronounced ally) is the first over-the-counter, FDA-approved weight loss pill. The 60-mg capsules are available as a 60-count starter pack, a 90-count starter pack, and a 120-count refill.

Alli is comprised of a half-dose of the prescription-only weight loss medication known as Xenical. The active ingredient in both pills is Orlistat.

At this time, Alli is considered safe for long-term use.

How do I Get Alli?

Alli is available at mass-market retailers, drugstores, and some online retailers. The 90-count starter pack costs around $60.The starter pack includes reference guides about the product, following a healthy diet, and exercise. Information about gaining access to online resources is also provided.

You must be 21 years of age or older to purchase the product.

What does Alli Do?

Alli is not an appetite suppresant. The purpose of Alli is to prevent your body from absorbing some of the fat you eat.

According to the official product Web site, myalli.com, the active ingredient (Orlistat) attaches to natural enzymes found in your body’s digestive system.

• The prospect of an anti-obesity drug, alli, that can be purchased over-the-counter is exciting news for millions of overweight Americans and Europeans. A reduced strength formulation of weight-loss drug Xenical (orlistat), alli is the only FDA-endorsed weight-loss drug available without a prescription.

• Xenical has a good safety record, and has shown itself to be moderately effective. But when alli is taken with a meal containing too much fat, side-effects can include “stools that may be hard to control.”

• The alli Report, updated daily, will provide the latest news and reviews related to alli (pronounced Al-eye), and the alli Forum provides a place for readers to ask questions — and share experiences — with diet pill alli
• For more information just go for a free consultation

  

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Buy Orlistat, a prescription medication from Roche Laboratories helps people suffering from obesity to lose weight quickly and reduce it substantially.It is in the form of a pill and is available through Onlineclinic after consulting one of our online UK registered Doctors.Orlistat is different from other weight loss drugs that act on the central Nervous system and brain to suppress appetite or to speed up metabolism such as Reductil, such that it works on your digestive system to block about one third of the fat in food and prevents it from being digested. There are enzymes in the stomach called as lipases that help digest(or break down) fat. Orlistat bonds with the enzyme to block digestion of fat in the stomach from the eaten food. The undigested fat cannot be absorbed and is eliminated through bowels. Thus 1/3rd of the fat your consume in the foods is blocked from absorbtion. It is always recommended that you eat healthier foods in your diet.

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GENERIC NAME: Orlistat
BRAND NAME: Xenical

How to Use This Medicine:
Capsule

Take this medicine with liquid at each main meal during the day. Each meal should contain no more than 30% of calories from fat.
Orlistat works by keeping your intestines from absorbing some of the fats from food. The undigested fat goes out of your body in your bowel movements.
This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:

If you miss a meal or eat a fat-free meal, you can skip your dose of this medicine.
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Unlike other commonly prescribed weight loss medications such as Reductil, Orlistat is not an appetite suppressant and does not have a direct effect on the brain. Instead, it works in your digestive system to block about one-third of the fat in the food you eat from being digested.

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Regrowth - A total of 18 posters.
Plenty of people have regrowth already in just about 1 month, particularly in the form of tiny small hairs on the temples. The majority reported vellus hairs growing on the temples, a couple reported regrowth in areas that have been bald for years, and many said existing vellus hairs are darkening and there are definitely signs that hairs are becoming thicker and switching into terminal hairs. It appears that for the time being, the positive feedbacks are predominantly about regrowth on the temples, only a couple mentioned regrowth on the crown.

MAXIMUM EFFECT
According to Avodart or dutasteride’s prescribing information, the maximum effect of dutasteride can be observed within 1 to 2 weeks. “After 1 and 2 weeks of daily dosing with dutasteride 0.5mg, median serum DHT concentrations were reduced by 85% and 90% respectively.” It was further reported that test patients treated with a daily dosage of 0.5mg dutasteride for 2 years, the median decrease in serum DHT concentration was over 92% for both year 1 and year 2 of the 2-year trial.

Dutasteride is the first dual inhibitor of both 5α-reductase Types 1 and 2 isoenzymes, with efficacy and safety proven in 3 randomized placebo-controlled trials, each 2 years in duration. The current report demonstrates that longer-term treatment over 48 months with dutasteride results in continuing improvements in urinary symptoms and flow rate, and further reductions in total and transition zone volume of the prostate in men with symptomatic benign prostatic hyperplasia (BPH). The reduction in risk of acute urinary retention and BPH-related surgery, seen in the double-blind phase, was durable over the 4-year term of the studies. The incidence of new onset adverse events remained low during the open-label extension phase, and less than 1% of patients discontinued therapy due to adverse events. These findings combined establish that the disease-modifying benefits of dutasteride are durable in long-term treatment. Dutasteride was also well tolerated in long-term use, with no new safety issues emerging over 4 years of treatment.

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Synonyms: Dutas, Veltride
Avodart (Dutasteride) is an androgen hormone inhibitor used in men to treat benign prostatic hyperplasia (BPH) which is swelling of the prostate. This medicine works by lowering the amount of the hormone responsible for prostate growth. Dutasteride reduces urinary blockage and improves urine flow. This medicine should not be used in women and children.

Dutasteride(avodart) is an FDA approved drug for Benign Prostate Hyperplasia with positive effects on hairloss. Dutasteride, which is taken in capsule form, has shown dramatic success in restoring hair to bald men in trials. It interferes with the production of 5-alpha-reductase enzymes that break down the male hormone testosterone and turn it into dehydrotestosterone (DHT) - DHT causes hair to thin dramatically in later life. Dutas has better DHT supression results than finasteride both Propecia and Proscar).

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