Generic Name: DUTASTERIDE - ORAL

This medication is used to shrink an enlarged prostate in men with a condition called benign prostatic hyperplasia. It works by lowering amounts of the hormone responsible for prostate growth (dihydrotestosterone). Dutasteride reduces urinary blockage and improves urine flow.

How To Use Avodart Oral

Take this medication by mouth once daily, with or without food. Swallow the medication whole.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. It may take 3 to 6 months before you notice an improvement of your symptoms.

This leaflet contains important information about Avodart 0.5mg soft capsules (referred to as Avodart from now on).

It is very important that you read this leaflet carefully before you start taking this medicine to make sure it is right for you.

The leaflet contains the following information about Avodart:

• 1. What Avodart does
• 2. Before you take Avodart
• 3. Taking Avodart with other medicines
• 4. How to take Avodart
• 5. If you take too many Avodart capsules
• 6. If you miss a dose
• 7. When you should STOP taking Avodart and possible side effects
• 8. Looking after your Avodart capsules

Regrowth - A total of 18 posters.
Plenty of people have regrowth already in just about 1 month, particularly in the form of tiny small hairs on the temples. The majority reported vellus hairs growing on the temples, a couple reported regrowth in areas that have been bald for years, and many said existing vellus hairs are darkening and there are definitely signs that hairs are becoming thicker and switching into terminal hairs. It appears that for the time being, the positive feedbacks are predominantly about regrowth on the temples, only a couple mentioned regrowth on the crown.

MAXIMUM EFFECT
According to Avodart or dutasteride’s prescribing information, the maximum effect of dutasteride can be observed within 1 to 2 weeks. “After 1 and 2 weeks of daily dosing with dutasteride 0.5mg, median serum DHT concentrations were reduced by 85% and 90% respectively.” It was further reported that test patients treated with a daily dosage of 0.5mg dutasteride for 2 years, the median decrease in serum DHT concentration was over 92% for both year 1 and year 2 of the 2-year trial.

Dutasteride is the first dual inhibitor of both 5α-reductase Types 1 and 2 isoenzymes, with efficacy and safety proven in 3 randomized placebo-controlled trials, each 2 years in duration. The current report demonstrates that longer-term treatment over 48 months with dutasteride results in continuing improvements in urinary symptoms and flow rate, and further reductions in total and transition zone volume of the prostate in men with symptomatic benign prostatic hyperplasia (BPH). The reduction in risk of acute urinary retention and BPH-related surgery, seen in the double-blind phase, was durable over the 4-year term of the studies. The incidence of new onset adverse events remained low during the open-label extension phase, and less than 1% of patients discontinued therapy due to adverse events. These findings combined establish that the disease-modifying benefits of dutasteride are durable in long-term treatment. Dutasteride was also well tolerated in long-term use, with no new safety issues emerging over 4 years of treatment.

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Synonyms: Dutas, Veltride
Avodart (Dutasteride) is an androgen hormone inhibitor used in men to treat benign prostatic hyperplasia (BPH) which is swelling of the prostate. This medicine works by lowering the amount of the hormone responsible for prostate growth. Dutasteride reduces urinary blockage and improves urine flow. This medicine should not be used in women and children.

Dutasteride(avodart) is an FDA approved drug for Benign Prostate Hyperplasia with positive effects on hairloss. Dutasteride, which is taken in capsule form, has shown dramatic success in restoring hair to bald men in trials. It interferes with the production of 5-alpha-reductase enzymes that break down the male hormone testosterone and turn it into dehydrotestosterone (DHT) - DHT causes hair to thin dramatically in later life. Dutas has better DHT supression results than finasteride both Propecia and Proscar).

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AVODART (DUTASTERIDE)

Avodart® (Dutasteride 0.5mg): The first dual-acting 5 alpha-reductase inhibitor for benign prostatic hyperplasia (BPH), approved by the FDA. Avodart® reduces the 2 enzymes responsible for the conversion of testosterone to DHT – which is a primary concern in hair loss. Where Propecia (Finasteride) only blocks one enzyme, by blocking both Avodart’s® result could be better. We can expect to see Avodart® officially on the market as a hair loss medication in 2006, if approved.

No word yet on Avodart® being approved for hair loss by the FDA. Avodart®, manufactured by GlaxoSmithKline (GSK), was approved in February, 2002 by the Food and Drug Administration (FDA), as a supplemental new drug application for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Dutasteride was originally assigned the tentative brand (trade) name of “Duogen.” The manufacturer GSK will market this drug, indicated for the treatment of BPH, under the name “Avodart™.” The drug became available in pharmacies in December, 2002. This new medicine for these patients will improve urinary symptoms, reduce risk of acute urinary retention (AUR), also reducing the risk of the need for BPH-related surgery.

General Precautions with Avodart:

Men taking Avodart should not donate blood until at least 6 months after their last dose to prevent pregnant women from receiving Avodart through a blood donation.

What should I tell my health care provider?

Tell your doctor if you have a history of:

• liver problems
• cancer of the prostate

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how Avodart works or Avodart may affect how your other medicines work.

What are some possible side effects of Avodart? (This is NOT a complete list of side effects reported with Avodart. Your health care provider can discuss with you a more complete list of side effects.)

The most common side effects are:

• impotence (trouble getting or keeping an erection)
• a decrease in libido (sex drive)
• breast enlargement and tenderness (gynecomastia)
• a decrease in the amount of semen released during sex

Avodart medication (news)

Propecia or Avodart, which inhibits the hair loss causing effects of DHT best?

Hereditary hair loss will affect about half of the American male population. Luckily, in the past few years there have been drug treatments developed that can slow down, completely stop, or even reverse hair loss in some men. While there is still no cure, pills such as Propecia or Avodart have given many men hope for holding on to the hair they have and maybe even regaining some of what they lost. When considering a medicinal regimen, many hair loss sufferers find themselves asking which medication is right for them.

dutasteride avodart effects side

Benefit of Avodart hair loss and prostate and Avodart side effects

Clinical trials, sponsored primarily by the manufacturer, have shown Avodart to be a treatment for prostate enlargement and similar to finasteride ( Proscar ). Further studies are needed to gain a clearer understanding of any clinically significant differences between Avodart and finasteride.

Avodart or Proscar?
Avodart is a dual 5alpha-reductase inhibitor for the treatment of benign prostatic hyperplasia. Avodart differs from finasteride as it inhibits both isoenzymes of 5alpha-reductase and results in near-complete suppression of serum dihydro-testosterone. Similar to finasteride, Avodart reduces serum prostatic specific antigen by approximately 50% at 6 months and total prostate volume by 25% in 2 years. Randomised, placebo-controlled trials conducted over 2 years have shown the efficacy of Avodart in symptomatic relief, and peak urinary flow rate, and reduction of acute urinary retention events and the need for surgery. The main Avodart side effects are erectile dysfunction, decreased libido, gynacomastia and ejaculation disorders. Avodart has been shown to possess tumor regression properties in vitro and its role in chemoprevention of prostate cancer is being evaluated in the ongoing Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial.

Dutasteride Avodart side effects
Possible side effects with Avodart are impotence (trouble getting or keeping an erection), a decrease in libido (sex drive), swelling or tenderness of the breast, and a decrease in the amount of semen released during sex. Avodart side effects could also include allergic reactions such as rash, itching, hives, and swelling of the lips or face. Another potential Avodart side effect is muscle aches. We have had 2 emails of this potential Avodart side effect and we can’t be sure the drug is responsible until we receive more information. See the bottom of this page for a fuller description of this Avodart side effect.
Lower urinary tract symptoms (LUTS) and male sexual dysfunction are highly prevalent in aging men, and are strongly linked. Various treatment strategies for benign prostatic hyperplasia may affect sexuality, with differences between drug classes and between drugs within a same class. The 5alpha-reductase inhibitors, finasteride and Avodart are associated with a greater side effect risk of erectile dysfunction, ejaculatory dysfunction (EjD) and decreased libido than is placebo. The Avodart side effect regarding sexual health is a concern for many men who are medicated with this drug. Passion Rx, Prostate Power Rx, or natural sex herbs could potentially be helpful in some men in reversing some of these Avodart related sexual side effects.

SIDE EFFECTS: Sexual problems (e.g., impotence, decreased interest in sex, decrease in the amount of ejaculate) may infrequently occur, but then go away as your body adjusts to the drug. This medication may also cause breast enlargement and/or tenderness. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.

PRECAUTIONS: Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, urinary tract disease, prostate cancer, any allergies. Men taking this medication should not donate blood until at least 6 months after they have stopped taking it to prevent exposure through a blood transfusion to a pregnant female. Since this drug can be absorbed through the skin, women who are pregnant or planning to become pregnant should not handle this medication. Any contact with this drug by a pregnant woman could result in abnormal external sex organs of a developing male fetus.